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Antibodies fragmentation

After purification, antibodies can be split up to eliminate their part Fc and so limit the crossed reactions while preserving the capacity of affinity and recognition of these. Indeed, the Fc region can be recognized by receivers Fc of certain cells, by factors rheumatoid, by proteins of the complement and by proteins A and G. 

Fragmentation of IgG in Fab and Fc

Fragmentation of IgG in F(ab’)²